Tang’s Group
The photo of Tang’s Group 2024 Spring
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portfolio
Portfolio item number 2
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publications
Type I macrophage activator photosensitizer against hypoxic tumors
Published in Chemical Science, 2021
(2nd author) This study explores a novel approach to photodynamic immunotherapy for treating cancer, addressing the challenges posed by the hypoxic nature and immunosuppressive tumor microenvironment
Recommended citation: Yang G., Lu S., Li C., et al. Type I macrophage activator photosensitizer against hypoxic tumors. Chem Sci 12, 14773-14780 (2021), https://doi.org/10.1039/D1SC04124J.
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Promoted NIR-II Fluorescence by Heteroatom-Inserted Rigid-Planar Cores for Monitoring Cell Therapy of Acute Lung Injury
Published in Small, 2021
(4th author) This study explores the development of NIR-II fluorophores for biomedical imaging.
Recommended citation: Li Y., Zha M., Kang T. et al. Promoted NIR-II Fluorescence by Heteroatom-Inserted Rigid-Planar Cores for Monitoring Cell Therapy of Acute Lung Injury, Small 18, 2105362 (2021), https://doi.org/10.1002/smll.202105362.
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Enhancing photodynamic inactivation via tunning spatial constraint on photosensitizer
Published in Science China Chemistry, 2023
(1st Co-first author†; With Han Minghao†, Gao Ji†, Wang Shuxian†) The study investigates how spatial constraints in different polymer matrices affect the photophysical behavior and antipathogen performance of a doped photosensitizer, demonstrating significant enhancements in singlet oxygen generation and pathogen elimination in polyurethane nanofibers compared to polyvinylchloride.
Recommended citation: Li C., Han M., Gao J. et al. Enhancing photodynamic inactivation via tunning spatial constraint on photosensitizer. Sci. China Chem. 67, 652–663 (2023). https://doi.org/10.1007/s11426-023-1751-2
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Facile Blinking Dyes with Spontaneous Enol-Keto Tautomerism for Super-Resolution Imaging of Subcellular Targets
Published in CCS Chemistry, 2024
(3th author) This study focuses on the development of live-cell permeable fluorophores for super-resolution imaging of subcellular targets.
Recommended citation: Gao J., Wu W., Zhou L. et al., Facile Blinking Dyes with Spontaneous Enol-Keto Tautomerism for Super-Resolution Imaging of Subcellular Targets. CCS Chem. 6, 2770-2782 (2024). https://doi.org/10.31635/ccschem.024.202303818
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Autologous Exosomes Loaded with a Rationally Designed Photosensitizer for Enhanced Photodynamic Therapy
Published in Chem. Commun., 2024
(2th Co-first author† with Qian yuyan†) The work is using the Machine Learning for find efficiently photosensitizers for exo target photodynamic cancer therapy.
Recommended citation: Qian Y., Li C., Gao J. et al., Autologous exosomes loaded with a rationally designed photosensitizer for enhanced photodynamic therapy. Chem. Commun. 60, 10180-10183 (2024). https://doi.org/10.1039/D4CC02168A
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Ir(III)-Based Photosensitizer-Loaded M1 Macrophage Exosomes for Synergistic Photodynamic Therapy
Published in Advanced Functional Materials, 2024
(8th author) This study focuses on the development of live-cell permeable fluorophores for super-resolution imaging of subcellular targets.
Recommended citation: Kang T., Wu X., Wang F. et al., Ir(III)-Based Photosensitizer-Loaded M1 Macrophage Exosomes for Synergistic Photodynamic Therapy. Adv. Funct. Mater. 34, 2408142 (2024), https://doi.org/10.1002/adfm.202408142
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talks
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Conference Proceeding talk 3 on Relevant Topic in Your Field
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teaching
BME5005 Nano-Biomedicine
Graduate course/Teaching assistant, Southern University of Science and Technology, Department of Biomedical and Engineering, 2021
Understand the basic principles of the application of nanoscience and nanotechnology in biomedicine, and learn about the research progress of new nanobiomaterials in biomedical diagnosis, treatment, intervention, and tissue regeneration and repair.
CHEM3550 Synthetic Chemistry Laboratory II
Undergraduate Course/Teaching assistant, Hong Kong University of Science and Technology, Department of Chemistry, 2024
This course was designed and introduced to suit chemistry major students who are enrolling in CHEM 3120 Organic Chemistry II and CHEM 3220 Inorganic Chemistry II, in which it provides students some hands-on experience in organic synthesis and metal complexes formation. Different spectroscopic methods will also be used for characterization of products. The topics of experiments covered in the laboratory course will be related to those taught in the lecture courses.
SCIE1120 Chemistry and Life
Undergraduate course/Teaching assistant, Hongkong University of Science and Technology, Department of Chemistry, 2024
The course aims to introduce students without an extensive science background into the chemistry of life and in life as well as some elementary units and mechanisms of life shaped by core chemical molecules and other compounds. Co-taught by lecturers from chemistry and life science, respectively, approximately one half of the course deals with an introduction into the chemical universe that makes life possible; simple sugars and complex carbohydrates, amino acids, peptides and proteins, DNA, RNA and lipids. Interactions and laws governing these substances and ways we can observe what they are doing are covered. The other half of the course is about how these compounds are involved in some of the basic mechanisms of life; from the functions and evolution of membranes to cells all the way up to humans and other organisms; areas covered include genetics and genomics, diseases, food and health, and biotechnology.
CHEM4250 Materials Preparation Laboratory
Undergraduate Course/Teaching assistant, Hong Kong University of Science and Technology, Department of Chemistry, 2024
This is a laboratory course for students to gain hands-on experiences in the preparation of modern materials. Students will have the opportunity to practice the synthesis of materials such as organic polymers, nanoparticles and solid materials. For CHEM students under the four-year degree only. Students with minor in CHEM may seek instructor’s approval for enrollment in the course.
CHEM1008 Introductory Chemistry
Undergraduate Course/Teaching assistant, Hong Kong University of Science and Technology, Department of Chemistry, 2024
This course targets science or engineering students with very little to no chemistry background. It provides a general introduction to basic principles of chemistry. Key topics include state of matters, atoms and elements, molecules and compounds, atomic structures and periodicity, molecular structures, quantities in chemical reactions, bonding theories, acids and bases, and solution chemistry.